Canine Genetic Testing
Alaskan Malamute Polyneuropathy
Alaskan Malamute polyneuropathy is a genetically distinct, recessive disease. A mutation in the NDRG1 gene has been identified as the causative mutation. Dogs that are homozygous for this mutation (i.e., have two copies of the mutation) will typically develop neuropathy before they reach 2 years of age.
Exercise Induced Collapse
Testing for the Exercise Induced Collapse (EIC) gene can be performed on blood, cheek swabs, dew claws and semen. The results are useful for owners in making decisions about the activities their dog can and cannot participate in, for breeders to assist them in making breeding decisions and for veterinarians as they are diagnosing dogs with possible neurological, neuromuscular or metabolic disorders.
Leonberger dogs may suffer from neuromuscular disease collectively termed Leonberger Polyneuropathy (LPN). We have mapped two major genetic risk loci and identified the causative mutations that we now term LPN1 and LPN2. The identified LPN1 mutation appears to be responsible for approximately 20% of the cases of polyneuropathy in Leonbergers, and LPN2 responsible for anther 20-25%. The other cases are apparently caused by different genetic mutations.
An inherited neurological disease, called “Neuronal Degeneration” or NDG, has been reported in Great Pyrenees dogs. This disease is inherited in an autosomal recessive manner. The University of Minnesota has identified a mutation within a disease-associated gene, and all affected dogs have two copies of this mutation. A genetic test allows owners to determine their dog’s status for this mutation in order to diagnose affected dogs and to guide future breeding decisions.
Persistent Müllerian Duct Syndrome
Persistent Müllerian Duct Syndrome (PMDS) is a reproductive disorder in which the uterus and other parts of the female reproductive tract develop in male dogs. The genetic mutation that causes PMDS has been reported in Miniature Schnauzer dogs, and the test that the University of Minnesota offers specifically checks for this mutation.
Hereditary xanthinuria is an autosomal recessive genetic disorder that results in excessive xanthine (a metabolic byproduct) in the urine. Genetic test results can be used to help guide medical management of affected dogs, identify dogs at risk even before they form stones, and to inform breeding decisions.