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A comprehensive investigation of Exercise-Induced Collapse (EIC) in Labrador Retrievers has been ongoing for over a decade, involving investigators from the University of Minnesota (EE Patterson, JR Mickelson, KM Minor), the University of Saskatchewan (SM Taylor, CL Shmon), and the Comparative Neuromuscular Laboratory at the University of California (GD Shelton). The objectives of this research have been to describe the syndrome so that it can be recognized by dog owners, veterinarians and trainers; to thoroughly evaluate affected dogs to try to establish an efficient means of diagnosis and to gain some insight into the cause of collapse; to determine the mode of inheritance and the genetic basis for EIC; and to develop a DNA test for the condition.
Here we summarize much of what we have learned about the genetic disorder of Exercise-Induced Collapse in Labrador Retrievers and other affected breeds.
Videos related to EIC
Border Collie Collapse (BCC)
A different collapse condition, not caused by the dynamin-1 EIC mutation, is being investigated in the following:
- Australian Cattle Dog
- Australian Kelpie
- Australian Shepherd
- Bearded Collie
- Belgian Malinois
- Belgian Tervuren
- Border Collie
- Collie
- Shetland Sheepdog
- Whippet
Submitting a sample
EIC test result interpretation & OFA application
Step 1 - Select instructions for your sample type
- Blood sample protocol (pdf)
- Cheek swab protocol (pdf)
- Dew Claw & Tail Docking protocol (pdf)
- Semen sample protocol (pdf)
Step 2 - Complete your submission form(s)
Step 3 - Fees & Payment
- 1-3 Dogs - $65 each
- 4 or more - $58 each
Need cheek swabs? Cheek swabs are not included in the purchase price. Links to several purchasing options are available within the cheek swab protocol (pdf).
Step 4 - Ship your sample(s)
Scientific references
A canine dynamin 1 mutation is highly associated with the syndrome of exercise-induced collapse.
Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR.
Nature Genetics 2008; 40(10): 1235-1239
Exercise Induced Collapse of Labrador Retrievers: Survey results and preliminary investigation of heritability.
Taylor SM, Shmon CL, Shelton GD, Patterson EE, Minor K, Mickelson JR.
Journal of the American Animal Hospital Association, November 2008; 44: 295-301.
Exercise-induced Weakness/Collapse in Labrador Retrievers
Taylor SM.
In LP Tilley and FW Smith (eds), 2008, Blackwell's Five Minute Veterinary Consult: Canine and Feline (4 th edition). 458-459.
Evaluations of Labrador Retrievers with Exercise Induced Collapse, including response to a standardized strenuous exercise protocol.
Taylor SM, Shmon CL, Adams VJ, Mickelson JR, Patterson EE, Shelton GD.
Journal of the American Animal Hospital Association, January 2009.
Exercise intolerance in retrievers.
Cosford KL, Taylor SM.
Veterinary Medicine, February 2010; Vol 105 No 2:64-75.
Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.
Minor, K.M., Patterson, E.E., Keating, M.K., Gross, S.D., Ekenstedt, K.J., Taylor, S.M., Mickelson, J.R., 2011.
The Veterinary Journal. doi:10.1016/j.tvjl.2011.06.022.
Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.
Furrow, E, Minor, K.M., Taylor, S.M., Mickelson, J.R., Patterson, E.E., 2013.
J AM Vet Med Assoc, No. 6, March 15, 2013: 786-791.