Dynamin-1 Associated Exercise-Induced Collapse

Labrador retriever standing on a hillside

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A comprehensive investigation of Exercise-Induced Collapse (EIC) in Labrador Retrievers has been ongoing for over a decade, involving investigators from the University of Minnesota (EE Patterson, JR Mickelson, KM Minor), the University of Saskatchewan (SM Taylor, CL Shmon), and the Comparative Neuromuscular Laboratory at the University of California (GD Shelton). The objectives of this research have been to describe the syndrome so that it can be recognized by dog owners, veterinarians and trainers; to thoroughly evaluate affected dogs to try to establish an efficient means of diagnosis and to gain some insight into the cause of collapse; to determine the mode of inheritance and the genetic basis for EIC; and to develop a DNA test for the condition.

Here we summarize much of what we have learned about the genetic disorder of Exercise-Induced Collapse in Labrador Retrievers and other affected breeds.

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Due to time related lab constraints the Veterinary Diagnostic Laboratory (VDL) is not currently accepting samples for EIC testing.

We recommend the UC Davis VGL as a source for EIC testing.

In Europe, the test is performed by Laboklin


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EIC test result interpretation & OFA application

Scientific references

A canine dynamin 1 mutation is highly associated with the syndrome of exercise-induced collapse.
Patterson EE, Minor KM, Tchernatynskaia AV, Taylor SM, Shelton GD, Ekenstedt KJ, Mickelson JR. 
Nature Genetics 2008; 40(10): 1235-1239

Exercise Induced Collapse of Labrador Retrievers: Survey results and preliminary investigation of heritability.
Taylor SM, Shmon CL, Shelton GD, Patterson EE, Minor K, Mickelson JR.
Journal of the American Animal Hospital Association, November 2008; 44: 295-301.
Exercise-induced Weakness/Collapse in Labrador Retrievers 
Taylor SM.
In LP Tilley and FW Smith (eds), 2008, Blackwell's Five Minute Veterinary Consult: Canine and Feline (4 th edition). 458-459.
Evaluations of Labrador Retrievers with Exercise Induced Collapse, including response to a standardized strenuous exercise protocol. 
Taylor SM, Shmon CL, Adams VJ, Mickelson JR, Patterson EE, Shelton GD.
Journal of the American Animal Hospital Association, January 2009.
Exercise intolerance in retrievers.
Cosford KL, Taylor SM.
Veterinary Medicine, February 2010; Vol 105 No 2:64-75.
Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.
Minor, K.M., Patterson, E.E., Keating, M.K., Gross, S.D., Ekenstedt, K.J., Taylor, S.M., Mickelson, J.R., 2011. 
The Veterinary Journal. doi:10.1016/j.tvjl.2011.06.022.
Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.
Furrow, E, Minor, K.M., Taylor, S.M., Mickelson, J.R., Patterson, E.E., 2013.
J AM Vet Med Assoc, No. 6, March 15, 2013: 786-791.