FEHI - Feline SEHI for OA
Kelly Bergsrud, CVT
Research Study Technician Specialist
[email protected]
612-624-9597
Study title
Towards a new treatment for feline osteoarthritis: Soluble epoxide hydrolase inhibition
Purpose of study
The objective of this study is to evaluate whether a new painkiller is able to provide pain relief in cats with arthritis, a type of joint inflammation that causes pain and is highly common in cats.
Eligibility criteria
Cats must:
- Be indoor only
- Be experiencing noticeable specific mobility problems
- Have confirmed evidence of arthritis and decreased muscle mass on x-rays
- Considered healthy or with a co-morbidity that is clinically well-controlled
- IBD: with episodes less than once weekly
- Hyperthyroidism: euthyroid with methimazole, I-131, or y/d diet
- Hypertension: normotensive with medication (amlodipine, enalapril, or benazepril)
- CKD: Iris stage 1-3, stable creatine and weight over 6 months
- Not be pregnant
- Discontinue any anti-inflammatory or other medication (unless stated above for stable disease) for at least one week before enrollment
- Ok to be on Solensia, prescription diet, or nutritional supplement if has been receiving for at least 3 months prior to study enrollment
- Have a stable daily living environment for the 7 week duration of the study
- Receive oral medication without difficulty/stress
Procedures
Day 0 (enrollment): Clinical assessment with disclosure of medical history taken. Physical examine ; blood and urine collected and radiographs taken to confirm osteoarthritis. Go over use of an activity monitor to be worn on collar around your cat's neck. Instructions on giving oral medications and how to fill out the daily log will be provided.
Week 1 (days 1-6): Acclimation week. No medication given this week. Your cat will start to wear the collar with the activity monitor on it. Offer an empty pill pocket daily.
Week 2 (days 7-13): First treatment week. Medication (either placebo or EC1728) given twice daily. Keep track of daily dosing on study sheet.
Day 13 visit: Exam given; blood and urine collected; download data from activity monitor
Weeks 3-4 (days 14-27): Washout weeks. No medication given these weeks. Your cat will continue to wear the collar and continue to offer one pill pocket daily.
Week 5 (days 28-34): Second treatment week. Medication (either placebo or EC1728, whichever was not given in the first treatment week). Keep track of daily dosing on study sheet.
Day 34 visit: Exam given, blood and urine collected; download data from activity monitor. Return filled out study forms, emtpy vials and unused medication.
Weeks 6-7 (days 35-48): Additional weeks of wearing the collar, no medication given during this period. You will be asked to return the activity monitor and collar at the end of this time.
Costs
The study will cover all the costs of the visits as mentioned above. Any medication and equipment needed to complete the study will be provided to you.
Owners will be financially responsible for any unforeseen complications during the study, whether they are related to the study or not.