COED study: Part 2

animated gif of various dogs
Principal Investigator
Jaime Modiano, VMD, PhD
Perlman Professor of Oncology and Comparative Medicine, Veterinary Clinical Sciences

Mitzi Lewellen
[email protected]

** Please read the whole page before clicking "I'm interested" **

Current status: Ongoing but enrollment closed

Study title

COED study: Early Detection of Canine Osteosarcoma

Purpose of study

Osteosarcoma is a common disease of dogs, with tens of thousands of new cases diagnosed each year in the United States. This disease is treatable, but not curable. Even with the best available standard of care, about 65% of dogs with osteosarcoma will die or be euthanized due to their disease within one year of diagnosis, more than 80% within two years, and more than 90% within three years. 

This project is designed to develop a reliable, minimally invasive blood-based test for early detection of canine osteosarcoma. Such a test could then be combined with strategic and rationally-designed treatments to kill the tumors before they form. Since all large- and giant dogs have an elevated risk of bone cancer, this work has the potential to benefit a multitude of breeds, as well as mixed-breed dogs.

Eligibility criteria

  • Be a purebred dog of one of six breeds: Golden Retriever, Great Dane, Irish Setter, Irish Wolfhound, Leonberger, or Rottweiler. Be able to provide a pedigree or AKC number. 
  • Be another large breed dog or mixed breed dog, must weigh more than 66 pounds, with a body condition score less than or equal to 6 out of 9 (as attested by a veterinary health professional)
  • Be healthy and aged 4.5 years or more
  • Live in the contiguous 48 states of the U.S.
  • Never had any type of cancer
  • Has no undiagnosed "lumps" or "bumps"


  • Owners will work with their veterinarian to submit blood sample(s): one at enrollment and additional samples may be requested
  • Sample instructions will be provided to the owner's local veterinarian. Local veterinarians must be able to process samples on-site for serum and plasma. 
  • Samples require FedEx overnight shipping - either the veterinary practice is able to ship or the owner will need to take the samples to FedEx for this.
  • Owners will be asked to complete follow up surveys at 6-month intervals regarding the health of their dog
  • Owners will be asked to keep the study team updated with any changes of ownership, address, and veterinarian

If you are interested, please click the "I'm interested" button above. You will complete a questionnaire which will submit to the study team. Someone on the study team will be in touch to go over the study in more detail.


There are no costs to participation in the study, however owners may incur costs for the sampling by their veterinarian.