AMPs: canine pyoderma topical treatment study

Principal Investigator
Sandra Koch, DVM, MS Diplomate ACVD
Professor, Dermatology, Veterinary Clinical Sciences

Helena Montin, DVM
Veterinary Medical Resident
[email protected]


Andrea Chehadeh, CVT
Research Study Technician Specialist
[email protected]

Current status: Open and enrolling

Study title

Efficacy and safety of a ceragenin-based hydrogel to treat canine superficial pyoderma - A randomized, double-blind, placebo controlled clinical trial

Purpose of study

Superficial bacterial skin infections are common skin problems in dogs that can often aggravate the primary disease. The frequent and non-judicious use of systemic antibiotic therapy to treat these infections has led to a significant increase in multidrug-resistant bacterial skin infections. Thus, the search for new treatments with less ability to induce bacterial resistance has become the main goal of many researchers. Antimicrobial peptides (AMPs) have demonstrated broad-spectrum action against bacteria and are an attractive target for the development of new antimicrobials as they do not lead to multidrug-resistant bacterial infections. The purpose of this study is to investigate the efficacy and safety of a topical product containing ceragenin, a mimicker of AMPs, on superficial bacterial skin infection in dogs. 

Eligibility criteria

  • Dogs of any age, gender, or breed allowed
  • Diagnosed with superficial bacterial skin infection (pyoderma)
  • Overall healthy, except for skin infection 
  • Allowed to have some other controlled diseases, discuss prior to enrollment 
  • Cannot be taking other topical treatments or be willing to discontinue 7+ days prior to enrollment
  • Flea and tick control ok if been on and willing to maintain during study
  • Non-antimicrobial systemic medications allowed if dog has to have been on them at least 4 weeks and willing to continue for duration of study
  • Allergen-specific immunotherapy is allowed if treatment has been given for at least a year


Enrolled dogs will have 3 visits one week apart (Days 0, 7, 14). Visits will consist of a physical exam, photographs of pyoderma, assessment of disease severity, skin cytology +/- aerobic culture and sensitivity.

At home procedures consist of applying a topical spray gel twice daily for 14 days. The study will provide all that is necessary. 


There is no cost to participate in this study.