Mark Osborn , PhD
Assistant Professor, Department of Pediatrics
Contact
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Affiliations:
Titles
Faculty Member, Division of Pediatric Blood and Marrow Transplantation & Cellular Therapy
Research Scientist, Pediatric Blood and Marrow Transplant (BMT) Center
Faculty, Masters Program in Stem Cell Biology
Education
PhD, University of Minnesota, 2009.
Biography
Dr. Osborn is an Assistant Professor in the Department of Pediatrics, Division of Blood and Marrow Transplantation. He is also a member of the Cancer Center. Dr. Osborn received his PhD degree from the University of Minnesota in 2009 in the laboratory of Dr. Bruce R. Blazar, MD.
Research
Research Summary
Dr. Osborn's current research is focused on gene and cellular therapy for disorders treated by hematopoietic cell transplantation including: Fanconi anemia, epidermolysis bullosa, and Hurler syndrome. This involves utilizing a patient's own cells for precision gene targeting and correction of their disease causing mutation. Genome editing nucleases and multiple terminally differentiated and stem cell populations are utilized towards optimizing ex vivo cellular therapies.
Gene Therapy
- Non-viral gene transfer for the treatment of inborn errors of metabolism.
Genome Editing
- Correction of disease specific mutations in a precise manner using homologous recombination.
Cellular Therapy
- Ex vivo correction of murine and human adult stem cells.
Honors and Recognition
Best abstract award, Pediatrics Research, Education, and Scholarship Symposium (PRESS), University of Minnesota Medical School
Meet the Investigator profile, Journal of Investigative Dermatology
Children’s Cancer Research Fund Butterfly Award, Medical Category
Basic Science Paper of the Year Award, Department of Pediatrics, University of Minnesota
Innovator in Basic Science Award, Department of Pediatrics, University of Minnesota
Professional Memberships
Member, American and European Societies for Gene and Cellular Therapy.