Bruce Walcheck, PhD

Professor, Department of Veterinary and Biomedical Sciences
Bruce Walcheck


Office Phone
Office Address

295B AS/VM Building
1988 Fitch Avenue
Saint Paul, MN 55108
United States


Professor, Department of Veterinary and Biomedical Sciences
Faculty, Microbiology, Immunology and Cancer Biology (MICaB) Ph.D. Graduate Program
Faculty, Masters Program in Stem Cell Biology
Faculty, Comparative and Molecular Biosciences (CMB) Ph.D. Graduate Program


PhD, Immunology, Montana State University


BS, Microbiology, Montana State University


Postdoctoral fellow, Boehringer Ingelheim Pharmaceuticals

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Research Mission

My lab studies various aspects of leukocyte biology and innate immunity. Our focus includes neutrophils, typically the first leukocyte population to be recruited to sites of bacterial infection, and natural killer (NK) cells, which play a key role in killing virus-infected cells and cancer cells. The cell surface expression levels of many receptors important for the function of these leukocyte populations are regulated by a process referred to as ectodomain shedding. We are interested in manipulating this process to improve leukocyte function during disease.


  • Leukocyte biology
  • Flow Cytometry
  • Immunology
  • Inflammation


Various receptors expressed on the surface of leukocytes that are critical for their function are regulated by a process known as “ectodomain shedding”, which is mediated by the metalloprotease ADAM17. We are actively studying this process to manipulate leukocyte function, such as to enhance tumor cell killing by NK cells. 


Selected publications

Dr. Walcheck, PubMed



  • CVM6911 - Veterinary Immunology, Instructor