Persistent Müllerian Duct Syndrome
Persistent Müllerian Duct Syndrome (PMDS) is a reproductive disorder in which the uterus and other parts of the female reproductive tract develop in male dogs. An important consequence of this disease is cryptorchidism (undescended testicles), which occurs in ~50% of affected dogs and causes infertility, as well as increased risk for testicular tumors. The external genitalia can be otherwise normal, making it easy to overlook PMDS as the underlying cause of cryptorchidism. Female dogs are not affected by this disease.
Note: Cryptorchidism has many potential causes, of which PMDS is only one.
Breeds reported to have Persistent Müllerian Duct Syndrome
The genetic mutation that causes PMDS has been reported in Miniature Schnauzer dogs, and the test that we offer specifically checks for this mutation. We believe that the mutation is relatively common in this breed (~25% carrier rate, ~2% genetically affected). Mutation screening has not been reported in other breeds. However, PMDS has been described in the Papillon, Belgian Malinois, Leonberger, Doberman Pinscher, Basset Hound, and English Cocker Spaniel. It is unknown if these breeds have the same mutation that causes the disorder in Miniature Schnauzers or if there are distinct mutations present.
Scientific References
Contact Us
Canine Genetics Lab
University of Minnesota
1988 Fitch Ave
AS/VM 295
St. Paul, MN 55108
[email protected]
612.624.5322
z.umn.edu/caninegenetics
Step 1 - Select instructions for your sample type
Step 2 - Complete your submission form(s)
Step 3 - Submit Payment
Fees
- 1-3 Dogs - $65 ea.
- 4 or more - $58 ea.
Need cheek swabs? Cheek swabs are not included in the purchase price. Links to several purchasing options are available within the cheek swab protocol.
Step 4 - Ship your sample(s)
Result Interpretation
Canine Genetic Testing
- 2,8- Dihydroxyadenine Urinary Stones
- Alaskan Malamute Polyneuropathy
- Exercise Induced Collapse
- Great Pyrenees Health Panel
- Hereditary Calcium Oxalate Urolithiasis, Types 1 & 2
- Inflammatory Myopathy (Myositis)
- Leonberger Health Panel
- Leukoencephalomyelopathy
- Persistent Müllerian Duct Syndrome
- Saint Bernard Laryngeal Paralysis & Polyneuropathy
- Sarcoglycan Deficient Muscular Dystrophy
- Toy Manchester Terrier / English Toy Terrier Health Panel
- Ullrich Congenital Muscular Dystrophy
- Xanthinuria
Canine Genetic Research
- Addison's Disease - Autoantibody Study
- Addison’s Disease – Genetics Study in Portuguese Water Dogs
- Addison’s Disease – Standard Poodle MHC Study
- Atypical Seizures / Paroxysmal Dyskinesia
- Border Collie Collapse
- Calcium Oxalate Urinary Stones
- Hyperlipidemia
- Idiopathic Epilepsy
- Immune-Mediated Hemolytic Anemia (IMHA)
- Leonberger Polyneuropathy / Laryngeal Paralysis
- Pulmonary Fibrosis
- Whippet Exercise Induced Hyperthermia