Ullrich Congenital Muscular Dystrophy

Labrador RetrieverA congenital muscular dystrophy associated with a mutation in the collagen VI gene has been identified in a family of Labrador Retriever dogs. At 4 months of age, clinical signs including angular limb deformities and carpal and tarsal contractures were present. Serum creatine kinase activity was persistently elevated. Histopathology of muscle biopsies showed a dystrophic phenotype and immunohistochemical stainings of fibroblasts and muscle  showed an absence of staining for collagen VI.

Research carried out at the University of Minnesota, the National Institutes of Health, and the University of California San Diego – Comparative Neuromuscular Laboratory identified a pathogenic mutation in the collagen VI gene with an autosomal recessive manner of inheritance.

We are now offering a genetic test which allows owners to determine their dog’s status for this mutation in order to diagnose affected dogs and to guide future breeding decisions.

Labrador with muscular dystrophy

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*Due to COVID-19 related lab closures, the Canine Genetics Lab is not currently accepting samples for genetic testing.

We are very sorry for the inconvenience, and will update our website as soon as we are able to resume lab operations.

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Canine Genetics Lab
University of Minnesota
1988 Fitch Ave
AS/VM 295
St. Paul, MN 55108

[email protected]<--break->


Fees & Payment

  • 1-3 Dogs - $65 ea.
  • 4 or more - $58 ea.

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