Sarcoglycan Deficient Muscular Dystrophy

DachshundA form of limb-girdle muscular dystrophy associated with a mutation in a muscle sarcoglycan gene has been identified in young miniature Dachshunds from Australia, South Africa, and the US. Clinical signs, first noted at approximately 6 months of age were variable and included exercise intolerance, stiff gait, myoglobinuria and dysphagia. The serum CK activity was markedly and persistently elevated. Histopathology of muscle biopsies showed a dystrophic phenotype and immunofluorescent stainings showed all sarcoglycan proteins were markedly decreased or absent.

Research carried out at the University of Minnesota and the University of California San Diego – Comparative Neuromuscular Laboratory identified a pathogenic mutation in the alpha sarcoglycan gene (SGCA). This mutation is inherited in an autosomal recessive manner. We now offer a genetic test which allows owners to determine their dog’s status for this mutation (clear, carrier, or affected) in order to guide future breeding decisions and to definitively diagnose affected dogs.

Dachshund

Contact Us

Canine Genetics Lab
University of Minnesota
1988 Fitch Ave
AS/VM 295
St. Paul, MN 55108

[email protected]
612.624.5322

z.umn.edu/caninegenetics


Fees & Payment

  • 1-3 Dogs - $65 ea.
  • 4 or more - $58 ea.

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Need cheek swabs?  Links to several purchasing options are available within the cheek swab protocol.