Sarcoglycan Deficient Muscular Dystrophy

DachshundA form of limb-girdle muscular dystrophy associated with a mutation in a muscle sarcoglycan gene has been identified in young miniature Dachshunds from Australia and the USA. Clinical signs, first noted at approximately 6 months of age were variable and included exercise intolerance, stiff gait, myoglobinuria and dysphagia. The serum CK activity was markedly and persistently elevated. Histopathology of muscle biopsies showed a dystrophic phenotype and immunofluorescent stainings showed all sarcoglycan proteins were markedly decreased or absent.

Research carried out at the University of Minnesota and the University of California San Diego – Comparative Neuromuscular Laboratory identified a pathogenic mutation in the alpha sarcoglycan gene. We are now offering a genetic test which allows owners to determine their dog’s status for this mutation in order to diagnose affected dogs and to guide future breeding decisions.

Dachshund

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*Due to COVID-19 related lab closures, the Canine Genetics Lab is not currently accepting samples for genetic testing.

We are very sorry for the inconvenience, and will update our website as soon as we are able to resume lab operations.

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Canine Genetics Lab
University of Minnesota
1988 Fitch Ave
AS/VM 295
St. Paul, MN 55108

[email protected]<--break->

z.umn.edu/caninegenetics


Fees & Payment

  • 1-3 Dogs - $65 ea.
  • 4 or more - $58 ea.

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