Sarcoglycan Deficient Muscular Dystrophy

DachshundA form of limb-girdle muscular dystrophy associated with a mutation in a muscle sarcoglycan gene has been identified in young miniature Dachshunds from Australia and the USA. Clinical signs, first noted at approximately 6 months of age were variable and included exercise intolerance, stiff gait, myoglobinuria and dysphagia. The serum CK activity was markedly and persistently elevated. Histopathology of muscle biopsies showed a dystrophic phenotype and immunofluorescent stainings showed all sarcoglycan proteins were markedly decreased or absent.

Research carried out at the University of Minnesota and the University of California San Diego – Comparative Neuromuscular Laboratory identified a pathogenic mutation in the alpha sarcoglycan gene. We are now offering a genetic test which allows owners to determine their dog’s status for this mutation in order to diagnose affected dogs and to guide future breeding decisions.

Dachshund

Contact Us

*We are now accepting samples for gentic testing & research.

Canine Genetics Lab
University of Minnesota
1988 Fitch Ave
AS/VM 295
St. Paul, MN 55108

[email protected]
612.624.5322

z.umn.edu/caninegenetics


Fees & Payment

  • 1-3 Dogs - $65 ea.
  • 4 or more - $58 ea.

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