Mathur Kannan, MS, PhD
My laboratory is investigating the contribution of the cell-surface protein CD38 to allergic airway disease characterized by airway inflammation and airway hyperresponsiveness. We focus on transcriptional and post-transcriptional mechanisms of regulation of expression of CD38 in airway smooth muscle. We investigate the contribution of CD38-derived and cyclic ADP-ribose-mediated intracellular calcium regulation to airway smooth muscle cell responses to spasmogens using pharmacological and genetic approaches. Our current interests are in defining the role of adenosine that is generated through the enzymatic activity of CD38 in lung inflammation, hyperresponsiveness, and airway remodeling in allergic airway disease.
Michael Murtaugh, PhD
We study innate and adaptive immune responses in swine, including porcine immunology and anti-viral immunity. Expertise includes gene expression analysis, recombinant protein expression, immune assays, B cell biology, genomics, transcriptomics, and gene and protein discovery. Basic research is translated into veterinary diagnostic tools and supports collaborations in xenotransplantation and porcine models of human diseases.