Presurgical grading of canine cutaneous mast cell tumors

dog with mast cell tumor by eyeStudy Title: The characterization of cytology and cell block in the presurgical grading of canine cutaneous mast cell tumors
Current Status: Active and enrolling
Principal Investigators: Jennifer Bouschor, DVM; Davis Seelig, DVM, PhD, DACVP
Contact: Dr. Bouschor: 612-626-8610, [email protected]
Dr. Seelig: 612-626-0471, [email protected]

Study Purpose:

Mast cell tumors are one of the most common skin tumors in dogs. These tumors may be benign (confined to one location, responsive to surgical removal) or highly malignant (recurring after removal and/or spreading locally and to distal organs). Currently, determination of the biologic behavior of these tumors is based on evaluation of tissue biopsies following surgical removal. Our study aims to improve the ability to predict tumor behavior by evaluating minimally invasive techniques that can be utilized prior to surgical removal.

Eligible dogs

  • Dogs with one or more previously diagnosed dermal (skin) mast cell tumor(s)
  • Scheduled for tumor removal or debulking surgery at the Veterinary Medical Center
  • Subcutaneous mast cell tumors are not included in this study

microscope view mast cell cytologyStudy Summary

  • This study will only sample tumors after they are removed by the VMC surgery service.
  • We will take aspirates in multiple locations within the removed tumor.
  • The excised mast cell tumor will then be submitted for histopathology (tissue analysis) by a board-certified anatomic pathologist.

Benefits of the study

  • The histopathology for the surgically removed dermal mast cell tumor(s) will be performed free-of-charge. This diagnostic test will aid your pet’s attending clinician in recommending follow-up medical care for your pet.
  • Additionally, you and your pet’s participation in this study will improve our ability to provide predictive information to clinicians and pet owners about mast cell tumors prior to surgical removal, potentially resulting in more tailored treatment options and enhanced presurgical diagnostics.

Costs of the study

  • Costs for histopathology of surgically excised dermal mast cell tumor(s) will be covered by this study.
  • Costs associated with surgical procedures, examination fees, other diagnostics including histopathology of any other lesions or any other medical or surgical procedures done at the VMC will be incurred by the client.

To learn more or to enroll, please contact Dr. Bouschor or Dr. Seelig (above). Contact via email is preferred.