eBAT compassionate care for dogs with hemangiosarcoma

golden retriever dog on grass


Status: On hold
Principal Investigator: 
Jaime Modiano
Antonella Borgatti

Dr. Modiano
[email protected]

Amber Winter
Research Technician Specialist
[email protected]

Study title

Compassionate use of recombinant bispecific angiotoxin simultaneously targeting EGFR and uPAR (eBAT Compassionate Care)

Purpose of study

Hemangiosarcoma is a type of sarcoma that is difficult to treat because of its aggressive behavior and rapid progression after diagnosis. We have shown that a novel EGF bispecific ligand targeted angiotoxin (eBAT) is safe in dogs and that it can kill hemangiosarcoma cells in the laboratory. We have treated 50 pet dogs with eBAT. The results from our previous trials show that eBAT doubled 6-month survival of dogs with hemangiosarcoma, from 38% to 77%, and more than doubled the expected 1-year survival, from about 15% to about 40%. Results of this study will provide information to develop a therapy for both dogs and humans with this incurable disease.

Eligibility criteria

  • Have diagnosed and staged hemangiosarcoma (HSA)
  • Performance score 0 or 1
  • Have an adequate supply of red blood cells (≥ 22% packed cell volume)
  • Have no severe comorbidities such as advanced kidney, liver or heart disease, or problems with blood clotting
  • Not taking cyclophosphamide
  • Not taking any alternative medications as therapy for their HSA
  • May be taking prednisone and/or nonsteroidal anti-inflammatory drugs (NSAIDS) to manage other chronic conditions
  • (Note – diagnostics performed elsewhere may be acceptable upon review. The abdominal ultrasound (required for staging) is required to be performed by a board-certified Radiologist. Thoracic radiographs will need to be reviewed by a board-certified radiologist.)


Owners must agree to the procedures required for their dog. Dogs must be screened at the University of Minnesota Veterinary Medical Center (VMC) prior to enrollment. The final decision to treat a dog will be at the discretion of the clinician after the screening appointment. Treatment with eBAT consists of 3 days, every other day, for a week (up to 8 days). Recheck and restaging appointments occur on Day 8, 21, 42, 63, 84, 105, 152, 180 and every 2-3 months thereafter. Rechecks and chemotherapy may be performed at the VMC or at the owner's veterinarian or oncology specialist.

Treatment with eBAT will be done exclusively at the University of Minnesota Veterinary Medical Center in St. Paul, MN