Cranial cruciate ligament reconstruction in dogs
Study Title: Intermediate-term fate of a citrate coated PET implant used for cranial cruciate ligament reconstruction in dogs: A pilot clinical trial
Current Status: On hold due to COVID-19
Principal Investigator: Michael Conzemius, DVM, PhD, DACVS
Contact: Andrea Chehadeh, Sr. Research Technician, [email protected]
STUDY UPDATE: We will not be considering new cases until April 1. We will update the web page as we get closer to April 1 to let people know if we will start enrolling again or if we will delay further based on information related to COVID-19.
Current treatment options for cranial cruciate ligament rupture (CCLR) have good owner satisfaction but there is still a high rate of progressive osteoarthritis (OA) post-operatively. The purpose of this study is to determine the safety and effectiveness of a citrate coated PET implant used for cranial cruciate ligament (CCL) reconstruction which could reduce the rate of post-operative OA. Polyethylene terephthalate (PET) ligaments have been used in humans since 1992.
Healthy adult dogs with cranial cruciate ligament rupture in one leg will be eligible for participation in this study. All dogs will have a thorough examination by the University of Minnesota Veterinary Surgery Service to determine if they meet all the requirements for this study, which include:
- Adult (>10 months), weight 30-45 kg (66-99 lbs)
- Palpable cranial drawer (>10mm) in the affected knee, tibial plateau angle < 30°
- No significant abnormalities on complete blood count and biochemistry profile
- Not pregnant, no bleeding disorders, or other major health impairments
Six-month study with four visits:
- Screening/Enrollment (Day 0) for exam, blood samples, X-ray of affected joint, force plate gait analysis (leash-walking dog over a force plate in the floor)
- Surgery under general anesthesia with arthroscopy to verify joint and cranial cruciate ligament replacement with PET implant
- Rechecks at 2 months and 6 months post-surgery. Month 6 visit includes arthroscopy under general anesthesia to view the health of the implant and overall condition of the joint.
Risks of the study:
As with any knee surgery, there are risks associated with the procedure. The study team will go over these prior to enrollment.
Cost of the study:
Costs of the initial screening, surgery and recheck visits described above will be paid by the study. Up to $2,000 in compensation will be provided for the treatment of study-related complications as long as care is provided by the Veterinary Medical Center.
To learn more or to enroll, please contact Andrea Chehadeh or Dr. Conzemius (above).