Anja K. Bielinsky, PhD
Professor, Biochemistry, Molecular Biology, and Biophysics
Associate Dean for Foundational Science, Medical School
Associate Director for Basic Shared Resources, Masonic Cancer Center (MCC)
Special Fellow, Leukemia and Lymphoma Society (1999-2001)
PhD, Heinrich Heine University, Düsseldorf, Germany, 1995
American Cancer Society Scholar (2002-2006),
Leukemia and Lymphoma Society Scholar (2008-2013)
Regulation of DNA replicationCell cycleCancer
- Alver, R.C., T. Zhang, A. Rajan, S. Das-Bradoo and A. K. Bielinsky, 2014. The N-terminus of Mcm10 is important for interaction with the 9-1-1 clamp and in resistance to DNA damage. Nucleic Acids Res. 42: 8389-8404. (pubmed)
- Becker, J.R., H.D. Nguyen, X. Wang and A. K. Bielinsky, 2014. Mcm10 deficiencycauses defective-replisome-induced mutagenesis and a dependency on postreplicative repair. Cell Cycle 13: 1737-1748. (pubmed)
- Thu, Y. M. and A. K. Bielinsky, 2014. Mcm10: one tool for all – integrity, maintenance and damage control. Semin. Cell. Dev. Biol. 30: 121-130. (pubmed)
- Ragland, R. L., S. Patel, R. Revard, K. Smith, A. A. Peters, A. K. Bielinsky, and E. J. Brown, 2013. RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells. Genes & Dev. 27: 2259-2273. (pubmed)
- Thu, Y. M. and A. K. Bielinsky, 2013. Enigmatic roles of Mcm10 in DNA replication, TIBS 38: 184-194. (pubmed).
- Nguyen, H. D., J. Becker, Y. M. Thu, M. Costanzo, E. N. Koch, S. Smith, K. Myung, C. L. Myers, C. Boone and A. K. Bielinsky, 2013. Unligated Okazaki fragments induce PCNA ubiquitination and a requirement for Rad59-dependent replication fork progression, PLoS ONE 8(6): e66379. (pubmed)
- Du, W., A. Josephrajan, S. Adhikary, T. Bowles, A. K. Bielinsky, and B. Eichman, 2013. Mcm10 self-association is mediated by an N-terminal coiled-coil domain, PLoS ONE 8(7):e70518. (pubmed)
- Haworth, J. C., Alver, R., Anderson, M. and Bielinsky, A. K. 2010. Ubc4 and Not4 regulate steady-state levels of DNA polymerase-alpha to promote efficient and accurate DNA replication, Molecular Biology of the Cell 21: 3205-3219. (pubmed)
- Nguyen, H. D. and Bielinsky, A. K. 2010. HDM2 ERKs PCNA, Journal of Cell Biology 190: 487-489. (pubmed)
- Alver, R. and Bielinsky, A. K. 2010. Termination at sTop2, Molecular Cell39: 487-489. (pubmed)
- Das-Bradoo, S., Nguyen, H. D. and Bielinsky, A. K. 2010. Damage-specific modification of PCNA, Cell Cycle 9: 3674-3679. (pubmed)
- Das-Bradoo, S., Nguyen, H. D., Ricke, R. M., Haworth, J. C. and Bielinsky, A. K. 2010. DNA ligase I deficiency triggers PCNA ubiquitination, Nature Cell Biology 12: 74-79. (pubmed)
- Das-Bradoo, S. and Bielinsky, A. K., 2009. Mapping replication initiation sites in eukaryotic genomes. Molecular Methods in DNA Replication (ed., John Walker and Jacob Dalgaard), Humana Press Inc.
- Raveendranathan, M. and Bielinsky, A. K., 2009. Analyzing origin activation patterns by copy-number change experiments. Molecular Methods in DNA Replication (ed., John Walker and Jacob Dalgaard),Humana Press Inc.
- Warren, E., Vaithiyalingam, S., Haworth, J., Greer, B., Smith, J.,Bielinsky, A. K., Chazin, W. and Eichman, B., 2008. Structural basis for DNA binding by replication initiator Mcm10, Structure (cover) 16:1892-1901. (pubmed)
- Bielinsky, A. K., 2007. Scarce but scary. Nature Genetics 39: 707-708. (pubmed)
- Chattopadhyay, S. and Bielinsky, A. K., 2007. Human Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replication. Molecular Biology of the Cell 18: 4085-4095. (pubmed)
- Bolon, Y. T. and Bielinsky, A. K. 2006. The spatial arrangement of ORC binding modules determines the functionality of replication origins in budding yeast. Nucleic Acids Research 34:5069-5080. (pubmed)
- Raveendranathan, M., Chattopadhyay, S., Bolon, Y.-T., Haworth, J. C., Clarke, D. J. and Bielinsky, A. K. 2006. Genome-wide replication profiles of S phase checkpoint mutants reveal fragile sites in yeast,EMBO J. 25:3627-3639. (pubmed)
- Ricke, R. M. and Bielinsky, A. K. 2006. A conserved Hsp10-like domain in Mcm10 is required for the stabilization of DNA polymerase-alpha in budding yeast, Journal of Biological Chemistry 281:18414-18425. (pubmed)
- Das-Bradoo, S., Ricke, R. M. and Bielinsky, A. K. 2006. Interaction between PCNA and di-ubiquitinated Mcm10 is essential for cell growth in budding yeast, Molecular & Cell Biology 26:4806-4817. (pubmed)
- Bielinsky, A. K. and Raveendranathan, M. 2006. Encircled: large-scale purification of replication origins from mammalian chromosomes,Molecular Cell 21: 735-737. (Pubmed)
- Ricke, R. M. and Bielinsky, A. K. 2005. Easy detection of chromatin binding proteins by the histone association assay. Biological Procedures Online, 7:60-69. (Online citation)
- Ricke, R. M. and Bielinsky, A. K. 2004. Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha. Molecular Cell, 16:173-185. (Medline citation)
- Bielinsky, A. K. 2003. Replication origins-why do we need so many?Cell Cycle 2:307-309. (Medline citation)
- Gerbi, S. A. and Bielinsky, A. K. 2002. DNA replication and chromatin.Curr. Opin. Genet. Dev. 12:243-248. Medline citation.
- Bielinsky, A. K., Blitzblau, H., Beall, E. L., Ezrokhi, M., Smith, H. S., Botchan, M. R., and Gerbi, S. A. 2001. Origin recognition complex binding to a metazoan replication origin. Current Biology 11:1427-1431.Medline citation.
- Bielinsky, A. K., and S. A. Gerbi, 2001. Where it all starts: eukaryotic origins of DNA replication. J. Cell Science 114: 643-651. Medline citation.
- Bielinsky, A. K., and S. A. Gerbi. 1999. Chromosomal ARS1 has a single leading strand start site. Molecular Cell 3:477-486. Medline citation.
- Gerbi, S. A., Bielinsky, A. K., Liang, C., Lunyak, V. V. and Urnov, F. D. 1999. Methods to map origins of replication in eukaryotes in "Eukaryotic DNA Replication: a practical approach" (ed., S. Cotterill),Oxford University Press, pp 1-41.
- Bielinsky, A. K., and S. A. Gerbi. 1998. Discrete start sites for DNA synthesis in the yeast ARS1 origin. Science 279:95-98. Medline citation.
- Gerbi, S. A., and Bielinsky, A. K. 1997. Replication initiation point mapping. Methods 13:271-280. Medline citation.